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Feasibility assessment of up-flow anaerobic sludge blanket treatment of sulfamethoxazole pharmaceutical

Yi Chen, Shilong He, Mengmeng Zhou, Tingting Pan, Yujia Xu, Yingxin Gao, Hengkang Wang

Frontiers of Environmental Science & Engineering 2018, Volume 12, Issue 5, doi: 10.1007/s11783-018-1069-0

Abstract:

The UASB system successfully treated sulfamethoxazole pharmaceutical

Keywords： Up-flow anaerobic sludge blanket (UASB)     Methane production     Sulfate reduction     Sulfamethoxazole pharmaceutical    

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Evaluating the impact of sulfamethoxazole on hydrogen production during dark anaerobic sludge fermentation

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 1, doi: 10.1007/s11783-023-1607-2

Abstract:

● SMX promotes hydrogen production from dark anaerobic sludge fermentation.

Keywords： Sulfamethoxazole     Hydrogen production     Dark anaerobic fermentation     Waste activated sludge    

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Mechanisms for simultaneous ozonation of sulfamethoxazole and natural organic matters in secondary effluent

Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 4, doi: 10.1007/s11783-020-1368-0

Abstract:

• SMX was mainly degraded by hydrolysis, isoxazole oxidation and double-bond addition.

Keywords： Sulfamethoxazole     Ozonation     Natural organic matters     Secondary effluent     Degradation mechanism    

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Removal of sulfamethoxazole and trimethoprim from reclaimed water and the biodegradation mechanism

Qinqin Liu, Miao Li, Xiang Liu, Quan Zhang, Rui Liu, Zhenglu Wang, Xueting Shi, Jin Quan, Xuhui Shen, Fawang Zhang

Frontiers of Environmental Science & Engineering 2018, Volume 12, Issue 6, doi: 10.1007/s11783-018-1048-5

Abstract:

The artificial composite soil treatment system could efficiently remove SMX and TMP by biodegradation mechanism.

Bacillus subtilis from column reactors degraded SMX and TMP efficiently.

Bacillus subtilis biodegrades TMP to NH4+, and then converts NH4+ to NO3–.

Keywords： Trimethoprim     Sulfamethoxazole     Biodegradation     Aerobic nitrification    

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Theoretical insights into influence of additives on sulfamethoxazole crystal growth kinetics and mechanisms

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 10,   Pages 1503-1515 doi: 10.1007/s11705-022-2294-4

Abstract: work, the influence of the initial chemical potential gradient, stirring speed, and polymer type on sulfamethoxazole

Keywords： insoluble drugs     polymer     inhibition crystallization     crystal growth kinetics     DFT calculations    

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Mesophilic and thermophilic anaerobic digestion of swine manure with sulfamethoxazole and norfloxacin

Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 5, doi: 10.1007/s11783-020-1342-x

Abstract:

• SMX addition had negative effect on acetoclastic methanogens in mesophilic AD.

Keywords： Pig manure     Antibiotics     Anaerobic digestion     Resistance genes     Microbial community    

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Dynamic response surface methodology using Lasso regression for organic pharmaceutical synthesis

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 2,   Pages 221-236 doi: 10.1007/s11705-021-2061-y

Abstract: To study the dynamic behavior of a process, time-resolved data are collected at different time instants during each of a series of experiments, which are usually designed with the design of experiments or the design of dynamic experiments methodologies. For utilizing such time-resolved data to model the dynamic behavior, dynamic response surface methodology (DRSM), a data-driven modeling method, has been proposed. Two approaches can be adopted in the estimation of the model parameters: stepwise regression, used in several of previous publications, and Lasso regression, which is newly incorporated in this paper for the estimation of DRSM models. Here, we show that both approaches yield similarly accurate models, while the computational time of Lasso is on average two magnitude smaller. Two case studies are performed to show the advantages of the proposed method. In the first case study, where the concentrations of different species are modeled directly, DRSM method provides more accurate models compared to the models in the literature. The second case study, where the reaction extents are modeled instead of the species concentrations, illustrates the versatility of the DRSM methodology. Therefore, DRSM with Lasso regression can provide faster and more accurate data-driven models for a variety of organic synthesis datasets.

Keywords： data-driven modeling     pharmaceutical organic synthesis     Lasso regression     dynamic response surface methodology    

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The removal of trimethoprim and sulfamethoxazole by a high infiltration rate artificial composite soil

Qinqin Liu,Miao Li,Fawang Zhang,Hechun Yu,Quan Zhang,Xiang Liu

Frontiers of Environmental Science & Engineering 2017, Volume 11, Issue 2, doi: 10.1007/s11783-017-0920-z

Abstract: Artificial composite soil treatment system with the high infiltration rate (1.394 m·d ) had a good removal efficiency of TMP (80%–90%) and SMX (60%–70%). The removal mechanism of TMP and SMX was mainly sorption and was related with hydrogeochemical process. Sulfamethoxzole (SMX) and trimethoprim (TMP), two combined-using sulfonamide antibiotics, have gained increasing attention in the surface water, groundwater and the drinking water because of the ecological risk. The removal of TMP and SMX by artificial composite soil treatment system (ACST) with different infiltration rates was systematically investigated using K , Na , Ca , Mg hydrogeochemical indexes. Batch experiments showed that the sorption onto the low-cost and commercially available clay ceramsites was effective for the removal of SMX and TMP from water. The column with more silty clay at high infiltration rate (1.394 m·d ) had removal rates of 80% to 90% for TMP and 60% to 70% for SMX. High SMX and TMP removal rates had a higher effluent concentration of K , Ca and Mg and had a lower effluent Na concentration. Removal was strongly related to sorption. The results showed that the removal of SMX and TMP was related to hydrogeochemical processes. In this study, ACST is determined to be applicable to the drinking water plants.

Keywords： Trimethoprim     Sulfamethoxazole     Artificial composite soil treatment     Hydrogeochemical processes     Ion exchange    

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Biodegradation of trace pharmaceutical substances in wastewater by a membrane bioreactor

Longli BO, Taro URASE, Xiaochang WANG

Frontiers of Environmental Science & Engineering 2009, Volume 3, Issue 2,   Pages 236-240 doi: 10.1007/s11783-009-0004-9

Abstract: The biodegradation of selected pharmaceutical micropollutants, including two pharmaceuticals with argued

Keywords： pharmaceuticals     membrane bioreactor     activated sludge     reaction kinetics    

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Removal of trimethoprim and sulfamethoxazole in artificial composite soil treatment systems and diversity

Qinqin Liu, Miao Li, Rui Liu, Quan Zhang, Di Wu, Danni Zhu, Xuhui Shen, Chuanping Feng, Fawang Zhang, Xiang Liu

Frontiers of Environmental Science & Engineering 2019, Volume 13, Issue 2, doi: 10.1007/s11783-019-1112-9

Abstract:

• Novel ACST allowed biodegradation to effectively remove adsorbed SMX and TMP.

• Ammonia and nitrite were efficiently removed in ACSTs and water quality was improved.

Keywords： Trimethoprim     Sulfamethoxazole     Reclaimed water     Biodegradation     Aerobic nitrification     Microbial community    

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Applications of the crystallization process in the pharmaceutical industry

Sohrab ROHANI

Frontiers of Chemical Science and Engineering 2010, Volume 4, Issue 1,   Pages 2-9 doi: 10.1007/s11705-009-0297-z

Abstract: The applications of the crystallization technique in the pharmaceutical industry as a purification andseparation process for the isolation and synthesis of pure active pharmaceutical ingredients (API),

Keywords： feedback     morphology     pulmonary     paracetamol     recognition    

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Machine learning-based solubility prediction and methodology evaluation of active pharmaceutical ingredients

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 4,   Pages 523-535 doi: 10.1007/s11705-021-2083-5

Abstract: The solubility data of 120 active pharmaceutical ingredients (APIs) in ethanol were considered in the

Keywords： solubility prediction     machine learning     artificial neural network     random decision forests    

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Internet of Things (IoT)–blockchain-enabled pharmaceutical supply chain resilience in the post-pandemic

Frontiers of Engineering Management   Pages 82-95 doi: 10.1007/s42524-022-0233-1

Abstract: During the COVID-19 pandemic, the current operating environment of pharmaceutical supply chain (PSC)

Keywords： pharmaceutical supply chain     Internet of Things     blockchain     resilience     post-pandemic era    

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Achieving biodegradability enhancement and acute biotoxicity removal through the treatment of pharmaceutical

Liang SUN, Can WANG, Min JI, Fen WANG

Frontiers of Environmental Science & Engineering 2011, Volume 5, Issue 3,   Pages 481-487 doi: 10.1007/s11783-011-0341-3

Abstract: Actual pharmaceutical wastewater was treated using a combined ultrasonic irradiation (US) and iron/cokebiotoxicity resulted mainly from the destruction of N,N-2 dimethyl formamide and aromatic compounds in the pharmaceutical

Keywords： internal electrolysis     ultrasonic     pharmaceutical wastewater     biodegradability     acute biotoxicity    

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Polymorphism of pharmaceutical molecules: perspectives on nucleation

Jie LU, Zhen LI, Xiaolin JIANG,

Frontiers of Chemical Science and Engineering 2010, Volume 4, Issue 1,   Pages 37-44 doi: 10.1007/s11705-009-0294-2

Abstract: Accordingly, the elucidation of the relationship between the particular polymorph of a pharmaceuticalmolecule and its functional properties is crucial to select the most suitable polymorph of the pharmaceuticalThis review briefly introduces recent advances in the discovery and control of the polymorphs of pharmaceutical

Keywords： development     Polymorphism     elucidation     controversial     relationship    

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Title Author Date Type Operation

Feasibility assessment of up-flow anaerobic sludge blanket treatment of sulfamethoxazole pharmaceutical

Yi Chen, Shilong He, Mengmeng Zhou, Tingting Pan, Yujia Xu, Yingxin Gao, Hengkang Wang

Journal Article

Evaluating the impact of sulfamethoxazole on hydrogen production during dark anaerobic sludge fermentation

Journal Article

Mechanisms for simultaneous ozonation of sulfamethoxazole and natural organic matters in secondary effluent

Journal Article

Removal of sulfamethoxazole and trimethoprim from reclaimed water and the biodegradation mechanism

Qinqin Liu, Miao Li, Xiang Liu, Quan Zhang, Rui Liu, Zhenglu Wang, Xueting Shi, Jin Quan, Xuhui Shen, Fawang Zhang

Journal Article

Theoretical insights into influence of additives on sulfamethoxazole crystal growth kinetics and mechanisms

Journal Article

Mesophilic and thermophilic anaerobic digestion of swine manure with sulfamethoxazole and norfloxacin

Journal Article

Dynamic response surface methodology using Lasso regression for organic pharmaceutical synthesis

Journal Article

The removal of trimethoprim and sulfamethoxazole by a high infiltration rate artificial composite soil

Qinqin Liu,Miao Li,Fawang Zhang,Hechun Yu,Quan Zhang,Xiang Liu

Journal Article

Biodegradation of trace pharmaceutical substances in wastewater by a membrane bioreactor

Longli BO, Taro URASE, Xiaochang WANG

Journal Article

Removal of trimethoprim and sulfamethoxazole in artificial composite soil treatment systems and diversity

Qinqin Liu, Miao Li, Rui Liu, Quan Zhang, Di Wu, Danni Zhu, Xuhui Shen, Chuanping Feng, Fawang Zhang, Xiang Liu

Journal Article

Applications of the crystallization process in the pharmaceutical industry

Sohrab ROHANI

Journal Article

Machine learning-based solubility prediction and methodology evaluation of active pharmaceutical ingredients

Journal Article

Internet of Things (IoT)–blockchain-enabled pharmaceutical supply chain resilience in the post-pandemic

Journal Article

Achieving biodegradability enhancement and acute biotoxicity removal through the treatment of pharmaceutical

Liang SUN, Can WANG, Min JI, Fen WANG

Journal Article

Polymorphism of pharmaceutical molecules: perspectives on nucleation

Jie LU, Zhen LI, Xiaolin JIANG,

Journal Article